Firstly, segregation within society has always been there. There have been people who have faced discrimination because of their ethnic backgrounds, stratum, gender, nationality, etc. Considering that these differences a fairly obvious in an individual, it is not a matter of learning to ignore it but rather to not let it be a reason to treat someone with prejudice. Transgendered and androgynous individuals have existed for a while now, yet society is still only taking the first steps towards learning to treat them equally.
Secondly, one might only assume that it feels like any other prejudice to be a transgender. It is the society that assumes that transgender individuals do not fit in a male or female category. However, for a trans, they clearly want to be put in the category of the gender that they have chosen to emulate. Society would need to see these individuals for who they want to be and treat them accordingly. This is the respect that any individual who faces prejudice might want to receive.
Thirdly, in the case of transgenders or any individual who isn’t easily accepted is the problem of knowledge. It is the lack of knowledge about a race that leads to people being unfamiliar with them. This is when people might tend to repel the unfamiliar. In such cases, it is essential to educate the new generations about how people of different are equally entitled to respect and fair treatment. In doing so, we might acclimatize the new generation to trans people, and this might enable them to see them as no different than any other person.