Gluten intolerance has traditionally been associated with gastrointestinal disorders, including celiac disease. However, gluten-derived peptides may affect many physiological functions beyond the gut, including cognition. Furthermore, gluten-derived peptides have been suggested to affect neuronal viability, morphology, and cell signaling pathways leading to inflammation and neurodegeneration, although the mechanisms involved remain poorly understood. Herein, we begin to investigate the pathways of gluten toxicity in neurons, using cultured SH-SY5Y cells as a disease model.
