Author: Ashanna Persaud
Mentor: José Fernández Romero
Institution: BMCC
Abstract:Emerging pathogens are a public health priority that require the use of biosafety containment laboratory levels, 3 or 4. Pseudoviruses are a solution to this limitation and allow scientists to work with them in a biosafety laboratory level 2. In this project, we explore the applications of pseudoviruses, how they can be produced and the limitations of these models. We discuss several viruses for which pseudoviral models have been created including, severe acute respiratory coronavirus 2 (SARS-CoV-2). Although pseudoviral models still have some challenges that must be solved, there is no doubt they are an invaluable tool to perform mechanistic studies and test neutralizing agents.
Assessing the Application of Pseudovirus in the Laboratory
