The game I played most recently was The Binding of Isaac: Rebirth, released in 2015 on Steam, Playstation 4, and Nintendo 3DS.
The main goal is to choose one of eleven characters and beat the final boss, while choosing diverging paths in order to get a different ending. There are 20 endings in total. Every ending unlocks more areas, bosses, and items as you progress.
The obstacles in-game are hordes of enemies that attack you in every room you enter. They gradually become more difficult as you progress, and change depending on the area. At the end of each stage there is a boss you have to defeat in order to progress.
Your reward for progressing comes in the form of items. There are over 200 + items in-game, each giving a different effect towards the player. Items can also stack and synergize to create a new experience every playthrough. Each boss fight, every encounter, and every path you choose will leave you with an item to further your build.
